I have been experimenting with the fonts available from typekit for web design, and was really disapointed with their rendering on Windows.
After a bit of digging in the settings of my Typekit browser of choice (Currently Safari 4 as my day-to-day browser Chrome 4 is not supported by the Typekit admin yet!) I found the following font settings within Safari.
There are 5 possible settings for font smoothing, and I recommend you try them all for yourself as the results depend on your screen (and eyes!)
Now why can’t Chrome and Firefox implement something like this?